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Abstract #60702 Published in IGR 16-4

Effects of Gelatin Hydrogel Loading Mitomycin C on Conjunctival Scarring in a Canine Filtration Surgery Model

Kojima S; Sugiyama T; Takai S; Jin D; Ueki M; Oku H; Tabata Y; Ikeda T
Investigative Ophthalmology and Visual Science 2015; 0:

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PURPOSE: To investigate the effects and toxicities of gelatin hydrogel (GH) loading mitomycin C (MMC) on intraocular pressure (IOP) and conjunctival scarring in a canine model of glaucoma surgery in comparison to conventional MMC application. METHODS: Glaucoma surgery models were made in six beagles. An MMC-loaded GH was implanted under the conjunctiva of one eye (GH-MMC group) and 0.04% MMC-soaked sponges were placed under the conjunctiva of the other eye (MMC group) for 5 five minutes. IOPs and bleb features were then assessed for 4four-weeks postoperative, followed by histological evaluation. The ratio of conjunctival area to scleral area, the densities of collagen and the numbers of fibroblasts, vessels, and proliferative cell nuclear antigen (PCNA)-positive cells were then quantified. RESULTS: In both groups, IOP reduction and bleb formation were maintained in a similar manner for 4four-weeks postoperative. No significant difference in the ratio of conjunctival area to scleral area was found between the two groups, however, c. Collagen density and the numbers of fibroblasts and vessels were significantly lower in the MMC-treated group than in the GH-MMC-treated group. No significant difference in PCNA-positive cells was found between the two groups. CONCLUSIONS: Implantation of MMC-loaded GH ameliorated toxicity to conjunctiva compared with the 5five-minute placement of MMC, howeverwhereas, its effect on IOP reduction and bleb formation was similar. These results suggest that using GH for the application of MMC is a safer method than the conventional application of MMC in glaucoma filtration surgery.

Dept Ophthalmology, Osaka Medical College, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.

Full article

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Classification:

5.3 Other (Part of: 5 Experimental glaucoma; animal models)
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)

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