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Abstract #60736 Published in IGR 16-4

Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment

Perera SA; Foo LL; Cheung CY; Allen JC; Chua D; Tham YC; Loon SC; Wong TY; Aung T
Journal of Glaucoma 2016; 25: 198-202

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PURPOSE: To investigate the agreement of vertical cup-to-disc ratio (VCDR) measured from Heidelberg Retina Tomograph 3 (HRT-3), high-definition optical coherence tomography (HD-OCT), and clinical grading. METHODS: A total of 933 consecutive subjects underwent optic nerve head imaging with HRT-3 and HD-OCT during a single visit. The vertical dimensions of the disc and cup were measured by slit-lamp examination using an eyepiece graticule. Bland-Altman plots evaluated the agreement in the VCDR obtained by the 2 instruments and clinical grading. RESULTS: We found a significant trend for the difference in VCDR measured clinically and with HRT and HD-OCT (P<0.001 for both). The mean VCDR differed significantly between clinical measurement and that evaluated by HRT and HD-OCT, respectively (0.40±0.12 vs. 0.37±0.21 and 0.40±0.12 vs. 0.50±0.14, P<0.001 for both), with significantly poor correlation (r=0.35 and 0.34, P<0.001 for both). CONCLUSIONS: In general, there is poor correlation and a lack of agreement of VCDR measured using HRT-3, HD-OCT, and clinical grading. HD-OCT has somewhat better agreement with clinical measurements of VCDR. Compared with clinical grading, HD-OCT tended to overestimate VCDR, whereas HRT-3 tended to underestimate it.

*Singapore Eye Research Institute & Singapore National Eye Center †Duke-NUS Graduate Medical School ‡Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Full article

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Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)

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