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Abstract #60741 Published in IGR 16-4
Long-Term Reproducibility of Macular Ganglion Cell Analysis in Clinically Stable Glaucoma Patients
Kim KE; Yoo BW; Jeoung JW; Park KHInvestigative Ophthalmology and Visual Science 2015; 0:
PURPOSE: To investigate the long-term reproducibility of macular ganglion cell analysis in clinically stable glaucoma patients using spectral-domain optical coherence tomography (SD-OCT). METHODS: One hundred and nine eyes of 109 clinically stable open-angle glaucoma patients with a localized retinal nerve fiber layer (RNFL) defect and a corresponding macular ganglion cell-inner plexiform layer (GCIPL) defect were included in this retrospective, longitudinal study. Clinical stability was defined as showing no change on serial structural (stereo-disc and RNFL photography) and functional (visual field progression analysis) assessments. Three serial SD-OCT (Cirrus-HD) peripapillary and macular scans taken at 6-month intervals were analyzed. Intraclass correlation coefficient (ICC), coefficient of variation (CV), test-retest standard deviation (TRTSD), and tolerance limit of area and angular width of GCIPL defect and GCIPL thickness measurements were assessed. RESULTS: The ICC of the GCIPL thickness parameters ranged from 0.966 to 0.992, and the CV from 2.0 to 5.5%. The TRTSD was the lowest for the average GCIPL thickness (1.45 µm), the highest for the minimum GCIPL thickness (3.42 µm), and varied from 1.54 to 2.16 µm for the sectoral measurements. The ICC, CV, and TRTSD were 0.993, 3.9%, and 5.32° for angular width, and 0.930, 6.7%, and 0.27 mm2 for area of GCIPL defect. Measurement variances (TRTSD) for the GCIPL measurements showed no significant association with the glaucomatous severity. CONCLUSIONS: The macular GCIPL thickness and deviation maps showed excellent long-term inter-visit reproducibility. Macular ganglion cell analysis can be considered as an effective means of monitoring glaucomatous progression in macula.
Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, 110-744, Korea (South), Republic of.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
