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Abstract #61060 Published in IGR 17-1
Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty
Champagne S; Anctil JL; Goyette A; Lajoie C; Des Marchais BJournal Français d'Ophtalmologie 2015; 38: 588-594
INTRODUCTION: Selective laser trabeculoplasty (SLT) is an effective and safe procedure to lower intraocular pressure (IOP) in the management of open-angle glaucoma. The post-laser inflammatory reaction could be positively implicated in SLT efficacy and the relevance of postoperative use of topical anti-inflammatory remains controversial. The goal of this study is to determine the effect of various anti-inflammatory treatments on intraocular pressure and on side effects following SLT. MATERIAL AND METHODS: A prospective, randomized, double-blind study with a control group was conducted. Ninety-six eyes of 67 patients with primary open-angle glaucoma who underwent SLT were enrolled in this study between March 2009 and March 2012. Eyes recruited in the study were randomized to receive either prednisolone acetate 1%, diclofenac 0.1% or a placebo. The 3 treatments were administered 4 times a day for 5 days following SLT. The intraocular pressures were measured at regular intervals during the 6-months follow-up period. Side effects were also evaluated with a questionnaire as well as with the ocular exam. RESULTS: The analysis of the relative IOP decrease over the 6-months period revealed a significant difference between the time points of follow-up (P<0.0001), but no group effect (P=0.2980). No significant difference regarding anterior chamber inflammation and discomfort was observed between the 3 groups. CONCLUSION: There was no difference in intraocular pressure reduction, intraocular inflammation or ocular discomfort post-SLT when comparing the 3 treatment modalities.
Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, G1V 0A6 Québec, QC, Canada; Centre universitaire d'ophtalmologie et Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec, 1050, chemin Sainte-Foy, G1S 4L8 Québec, QC, Canada.
Full articleClassification:
12.4 Laser trabeculoplasty and other laser treatment of the angle (Part of: 12 Surgical treatment)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
