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Abstract #61538 Published in IGR 17-1
The genetic mechanisms of primary angle closure glaucoma
Ahram DF; Alward WL; Kuehn MHEye 2015; 29: 1251-1259
Primary Angle Closure Glaucoma (PACG) is one of the most common types of glaucoma affecting over 15 million individuals worldwide. Family history and ethnicity are strongly associated with the development of the disease, suggesting that one or more genetic factors contribute to PACG. Although strictly heritable disease-causing mutations have not been identified, a number of recent association studies have pointed out genetic factors that appear to contribute to an individual's risk to develop PACG. In addition, genetic factors have been identified that modify PACG endophenotypes for example, axial length. Herein we review the current literature on this important topic.Eye advance online publication, 24 July 2015; doi:10.1038/eye.2015.124.
Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA.
Full articleClassification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
