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Abstract #61603 Published in IGR 17-1
Effect of glaucoma medications on 24-h intraocular pressure-related patterns using a contact lens sensor
Mansouri K; Medeiros FA; Weinreb RNClinical and Experimental Ophthalmology 2015; 43: 787-795
BACKGROUND: To study the circadian intraocular pressure-related (IOP) effects of ocular hypotensive medications using a contact lens sensor (CLS). DESIGN: University-based prospective, randomized, crossover trial. PARTICIPANTS: Twenty-three patients with primary open-angle glaucoma METHODS: Patients underwent ambulatory recording of IOP-related patterns for 24 hours in one eye during 3 monthly sessions using a CLS. Patients were untreated in session 1 (S1), were randomized to one of 4 classes of glaucoma drops for S2, and had a prostaglandin analog add-on for S3. MAIN OUTCOME MEASURES: Changes in IOP-related patterns were defined using 1) slopes from wake/sitting to sleep/supine, 2) cosinor rhythmometry modeling, and 3) area under receiver operating curve (AUC) of sleep period. RESULTS: Mean patient age was 63.8±11.8 years. Positive linear slopes were seen from wake/sitting to sleep/supine at S1 (17.1±14.2 mVeq/h) and S2 (5.5±23.9 mVeq/h) and negative slopes at S3 (-1.9±29.4 mVeq/h) (S1 to S2, p=0.01; S1 to S3, p=0.02). In the prostaglandin group, slopes changed significantly with introduction of drops (S1 to S2, p<0.024) while they did not in a mixed group combining the 3 other classes (S1 to S2, p=0.060). Overall, cosinor amplitudes were 98.4±46.5 mVeq (S1), 113.0±35.6 mVeq (S2), and 109.6±58.3 mVeq (S3) (S1-S2, p=0.23; S1-S3, p=0.66; S2-S3, p=0.93). AUC was 91.8±63.0 mVeq (S1), 76.3±102.7mVeq (S2), and 19.9±135.8 mVeq (S3). Differences between sessions were not statistically significant (S1-S2, p=0.541; S1-3, p=0.083; S2-S3, p=0.092). CONCLUSIONS: Prostaglandin analogs but not other medications seem to flatten the IOP-related increase at transition of the wake/sitting to the sleep/supine period but do not seem to have an effect on acrophase and amplitude.
Full article
Classification:
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
