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Abstract #61620 Published in IGR 17-1
Intrasubject Difference in CCT among POAG versus Normal Individuals
Yazdani S; Doozandeh A; Haghighat M; Akbarian S; Pakravan M; Yaseri MOptometry and Vision Science 2015; 92: 879-883
PURPOSE: To evaluate intrasubject asymmetry in central corneal thickness (CCT) among patients with primary open-angle glaucoma (POAG) as compared with that of normal subjects and to determine whether the eye with thinner cornea has more severe glaucomatous visual field damage. METHODS: In this case-control study, CCT of both eyes was measured using an ultrasonic pachymeter (UP-1000; Nidek Technologies, Gamagori, Japan) among POAG patients and normal subjects. The intrasubject difference in CCT was calculated and compared between the study groups; correlations between CCT and intraocular pressure (IOP), vertical cup-to-disc ratio (VCDR), and visual field defects were also evaluated. RESULTS: A total of 62 patients with bilateral POAG and 56 normal subjects were included. There was no significant difference between the study groups in terms of age, sex, and ocular parameters except for visual acuity, IOP, and VCDR. The POAG patients demonstrated significantly greater intrasubject asymmetry in CCT (8 ± 7 μm vs. 5 ± 3 μm; p = 0.041) and a higher prevalence of significant (>10 μm) intrasubject CCT difference (30.6 vs. 5.4%; p < 0.001) as compared with normal subjects. Although each higher level of glaucomatous damage was associated with 4-μm thinner CCT, the correlation was not statistically significant (95% confidence interval, -8 to 1 μm; p = 0.117; GEE analysis). No significant correlation was observed between CCT and IOP or VCDR (p = 0.302 and 0.137, respectively). CONCLUSIONS: Patients with POAG demonstrate a larger amount of intrasubject difference in CCT as compared with normal subjects.
*MD †MSc ‡PhD Ocular Tissue Research Center (SY) and Ophthalmic Research Center (SY, AD, MH, SA, MP, MY), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Full articleClassification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
