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Abstract #6179 Published in IGR 2-2
Vasorelaxing properties of carteolol in isolated porcine ciliary arteries
Kasper J; Champion C; Flammer J; Haefliger IOKlinische Monatsblätter für Augenheilkunde 2000; 216: 318-320
INTRODUCTION: Carteolol is a topical beta-blocker used in ophthalmology to decrease the intraocular pressure. This study investigates the vasoactive effect of carteolol in isolated porcine ciliary processes. MATERIAL AND METHODS: With a myograph system, isometric force measurements, quiescent vessels or vessels either precontracted with endothelin-1 (0.03 μm) or the thromboxane A2 analogue U 46619 (0.3 μm) were exposed, in cumulative manner, to increasing concentrations of carteolol (10 μm-3 mM). Vessels that had a functional endothelium were compared with vessels that had a non functional endothelium (intentionally and mechanically damaged). RESULTS: In quiescent vessels carteolol did not induce contractions. In contrast, in precontracted arteries, carteolol evoked marked relaxations which were endothelium-independent. CONCLUSIONS: In vitro, carteolol has a marked vasorelaxing effect on porcine ciliary arteries, however the clinical relevance of this observation for the care of glaucoma patients requires further evaluation.
Dr. J. Kasper, Laboratory of Ocular Pharmacology and Physiology, University Eye Clinic Basel, Basel, Switzerland
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)