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Abstract #6203 Published in IGR 2-2
Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties
Renzi G; Scozzafava A; Supuran CTBioorganic and Medicinal Chemistry Letters 2000; 10: 673-676
Reaction of aromatic/heterocyclic sulfonamides possessing free amino, imino or hydrazino moieties with 7-chloro-4-chloromethylcoumarin afforded a series of N-((7-chloro-4-coumarinyl)-methyl)- derivatives which showed effective inhibition of three carbonic anhydrase (CA) isozymes. Topical application within the rabbit eye of some of these compounds led to effective intraocular pressure lowering, due to CA inhibition within the ocular tissues, and reduced aqueous humor production.
Dr. G. Renzi, Universita degli Studi, Dipartimento di Scienze Farmaceutiche, Florence, Italy
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
