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Abstract #6255 Published in IGR 2-2
Outcome of trabeculectomy with intraoperative 5-fluorouracil
Kawazoe M; Okinami S; Saito I; Matsui Y; Oono S; Ishigooka HJapanese Journal of Clinical Ophthalmology 2000; 54: 993-997
The authors prospetively evaluated the effect of trabeculectomy with intraoperative 5-fluorouracil in 43 glaucoma eyes. The series comprised 26 high-risk and 17 low-risk eyes. The following eyes were defined as high-risk: past history of glaucoma or cataract surgery, cases under 30 years of age, glaucoma secondary to uveitis and neovascular glaucoma. The intraocular pressure (IOL) in the high-risk group averaged 27.7 ± 12.6 mmHg before surgery and 18.1 ± 7.5 mmHg at the last postoperative visit. The IOP in the low-risk group averaged 20.9 ± 5.1 mmHg before and 15.9 ± 5.4 mmHg after surgery. The success rate, or an IOP of 20 mmHg or less without medication at 24 months after surgery, was 29.7 ± 9.2% in the high-risk and 52.3 ± 9.8% in the low-risk group, when evaluated by life-table analysis. The success rate with antiglaucoma medications other than oral acetazolamide was 53.9 ± 9.8% in the high-risk and 63.6 ± 16.6% in the low-risk group. Main complications were choroidal detachment (23 eyes), superficial punctate keratitis (16 eyes), hypotonic maculopathy (seven eyes), and late-onset bleb leaks (one eye). The findings show that trabeculectomy with intraoperative 5-fluorouracil may not induce IOP control in high-risk glaucoma. LA: Japanese
Dr. M. Kawazoe, Department of Ophthalmology, Saga Social Insurance Hospital, 3-8-1 Minami Hyogo-machi, Saga-shi 849-0918, Japan
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
