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Abstract #6285 Published in IGR 2-2
Quantification of nitric oxide and cytokines in rabbit aqueous humor after neodymium:YAG laser capsulotomy
Er H; Guenduez A; Cigli A; Turkoz Y; Cekmen MOphthalmic Research 2000; 32: 106-109
PURPOSE: The purpose of this study was to evaluate the presence of nitric oxide (NO) and cytokines such as interleukin 1 beta, interleukin 2 receptor (IL-2R), interleukin 6 and tumor necrosis factor alpha on aqueous humor after Nd:YAG laser posterior capsulotomy. METHODS: Fifteen rabbits (30 eyes) with dense posterior capsule opacities underwent Nd:YAG capsulotomy four months after phacoemulsification cataract surgery. After general and topical anesthesia, Nd:YAG capsulotomy was performed using an equal number of shots and power setting on all eyes. Aqueous humor specimens were collected from each eye preoperatively and at 12, 24 and 48 hours after the surgery to determine NO and cytokine levels. RESULTS: The levels of NO and cytokines except IL-2R were significantly high as compared to preoperative levels in all eyes at 12 and 24 hours postoperatively (p < 0.05). Although the levels of NO and cytokines were higher than preoperative levels at 48 hours, the differences were not statistically significant (p > 0.05). CONCLUSION: These findings suggest that NO and cytokines appear to be potential inflammatory mediators in the occurrence of early inflammation following Nd:YAG posterior capsulotomy.
Dr. H. Er, Department of Ophthalmology, Turgut Ozal Medical Center, University of Inonu School of Medicine, Malatya, Turkey. hamdier@inonu.edu.tr
Classification:
12.15 Capsulotomy (Part of: 12 Surgical treatment)
