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Abstract #6292 Published in IGR 3-2
Patterns of open-angle glaucoma in the Barbados Family Study
Leske MC; Nemesure B; He Q; Wu SY; Hejtmancik JF; Hennis AOphthalmology 2001; 108: 1015-1022
OBJECTIVE: To describe the Barbados Family Study of open-angle glaucoma (OAG) and to present risk factors for OAG in siblings of study probands. DESIGN: An observational study of families of probands with OAG. PARTICIPANTS: Two hundred and thirty probands and 1056 relatives (from 207 families). METHODS: Probands and their family members underwent standardized examinations, including automated perimetry, applanation tonometry, ophthalmological evaluation, fundus photography, blood pressure, interview, and genotyping. Generalized estimation equation methods were used to evaluate risk factors. MAIN OUTCOME MEASURES: The presence of OAG in relatives, as defined by both visual field and optic disc findings, after ophthalmological exclusion of other causes. RESULTS: The median ages of probands and relatives were 68 and 47 years, respectively. In the 207 families, 29% of the probands had one relative with OAG, and 10% had two or more relatives affected. Of the 1056 family members, 10% had OAG, 13% had suspect OAG, and 6% had ocular hypertension. One-fifth of the 338 siblings had OAG (n = 67); they tended to be older and more often were male. Multivariate comparisons between siblings with and without OAG found that age, higher intraocular pressure (IOP), myopia, and lower diastolic blood pressure-IOP differences were related to OAG, whereas hypertension and diabetes were not. CONCLUSIONS: Based on standardized protocols and examinations, approximately one-quarter of the relatives had OAG or suspected OAG, despite their relatively young age. Risk factors for OAG in siblings were similar to risk factors in unrelated individuals. Analyses are ongoing to determine OAG inheritance and to localize potential gene(s) involved.
Dr M.C. Leske, Department of Preventive Medicine, University Medical Center at Stony Brook, HSCI 3086, Stony Brook, NY 11794-8036, USA. cleske@uhmc.sunysb.edu
Classification:
1.1 Epidemiology (Part of: 1 General aspects)
1.2 Population genetics (Part of: 1 General aspects)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
