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Abstract #6295 Published in IGR 3-2
Association of demographic, familial, medical, and ocular factors with intraocular pressure
Weih LM; Mukesh BN; McCarty CA; Taylor HRArchives of Ophthalmology 2001; 119: 875-880
OBJECTIVE: To describe the distribution and association of demographic, familial, medical, and ocular factors with intraocular pressure (IOP). METHODS: A cluster stratified random sample of urban and rural residents of Victoria, Australia, aged 40 years and older. Participants completed an interview and underwent a standardized dilated ophthalmic examination, including measurement of IOP with an electronic applanation tonometer (Tono-Pen). Glaucoma status (possible, probable, definite) was determined by a consensus panel. The main outcome measure was IOP. RESULTS: The mean age of the 4576 patients was 59 years, 53% were females, 32% had been born overseas, and 132 had open-angle glaucoma. Geometric mean (SD) IOP was 14.3 (± 1.5) mmHg. The relationship between IOP and nuclear sclerosis, iris color, and family history of glaucoma depended on glaucoma status. In those with glaucoma, family history of glaucoma and country of birth were significantly associated with IOP in multivariate models (model: r2 = 0.08, p = 0.01). In the group without glaucoma, place of residence, use of alcohol, iris color, vitamin E intake, and spherical equivalent were associated with IOP (model: r2 = 0.01, p = 0.006). CONCLUSIONS: In participants with glaucoma, genetic factors seem to be stronger predictors of IOP, while in those without glaucoma, lifestyle and physiological factors seem to play a greater role.
Dr L.M. Weih, Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Classification:
1.1 Epidemiology (Part of: 1 General aspects)
