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1 General aspects (0)   1.1 Epidemiology (4)   1.2 Population genetics (8)   1.3 Pathogenesis (7)   1.4 Quality of life (4)   1.5 Glaucomas as cause of blindness (0)   1.6 Prevention and screening (1) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (1)   2.2 Cornea (3)   2.3 Sclera (1)   2.4 Anterior chamber angle (0)   2.5 Meshwork (8)     2.5.1 Trabecular meshwork (0)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (4)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (0)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (0)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (3)   2.9 Ciliary body (3)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (2)   2.13 Retina and retinal nerve fibre layer (14)   2.14 Optic disc (13)   2.15 Optic nerve (1)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (2)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (7)   3.4 Molecular genetics (2)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (0)   3.5 Molecular biology incl. 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with intraocular tumors (2)     9.4.9 Glaucomas associated with elevated episcleral venous pressure (0)       9.4.10 Glaucomas associated with hemorrhage (0)     9.4.11 Glaucomas following intraocular surgery (0)       9.4.11.1 Ciliary block (malignant) glaucoma (0)       9.4.11.2 Glaucomas in aphakia and pseudophakia (0)       9.4.11.3 Epithelial, fibrous, and endothelial proliferation (0)       9.4.11.4 Glaucomas associated with corneal surgery (1)       9.4.11.5 Glaucomas associated with vitreoretinal surgery (0)     9.4.15 Glaucoma in relation to systemic disease (6)     9.4.20 Other (0) 10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy (3) 11 Medical treatment (1)   11.1 General management, indication (5)   11.2 Cholinergic drugs (1)   11.3 Adrenergic drugs (0)     11.3.1 Epinephrine (0)     11.3.2 Thymoxamine, dapiprazole (0)     11.3.3 Apraclonidine, brimonidine (12)     11.3.4 Betablocker (12)     11.3.5 Other (0)   11.4 Prostaglandins (32)   11.5 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Without tube implant (14)     12.8.2 With tube implant or other drainage devices (6)     12.8.3 Non-perforating (6)     12.8.4 Using laser (0)     12.8.5 Other (1)     12.8.10 Woundhealing antifibrosis (13)     12.8.11 Complications, endophthalmitis (7)   12.9 Trabeculotomy, goniotomy (2)   12.10 Cyclodestruction (5)   12.11 Cyclodialysis (1)   12.12 Cataract extraction (0)     12.12.1 Intracapsular (0)     12.12.2 Extracapsular (1)     12.12.3 Phacoemulsification (8)   12.14 Combined cataract extraction and glaucoma surgery (0)     12.14.1 Intracapsular (1)     12.14.2 Extracapsular (0)     12.14.3 Phacoemulsification (9)   12.15 Capsulotomy (0)   12.16 Vitrectomy (0)   12.17 Anesthesia (5)   12.20 Other (0) 13 Therapeutic prognosis and outcome (0)   13.1 Prognostic factors (0)   13.2 Outcome (0)     13.2.1 IOP (0)     13.2.2 Visual field (0)       13.2.2.1 Progression (0)       13.2.2.2 Improvement (0)     13.2.3 Other (0) 14 Costing studies; pharmacoeconomics (3) 15 Miscellaneous (2)

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Abstract #6327 Published in IGR 3-2

Hepatocyte growth factor is increased in the aqueous humor of glaucomatous eyes

Hu DN; Ritch R
Journal of Glaucoma 2001; 10: 152-157

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PURPOSE: To assess the concentrations of hepatocyte growth factor (HGF) in the aqueous humor of eyes with glaucoma compared to control eyes with cataract only. METHODS: Concentrations of HGF were measured in aqueous humor aspirates taken during anterior segment surgery from 84 patients, of whom 72 had glaucoma (38 cases of primary open-angle glaucoma (POAG), 17 angle-closure glaucoma (ACG), and 17 exfoliative glaucoma), and 12 had cataract only, using a sandwich enzyme-linked immunosorbent assay kit. RESULTS: HGF was detected in all samples. The concentration in eyes with cataract only was 563.3 ± 178.8 pg/ml (mean ± standard deviation), which was significantly lower than that in eyes with glaucoma (967.1 ± 514.7 pg/ml, p < 0.01). Eyes with exfoliative glaucoma had significantly higher HGF concentrations (1425.5 ± 586.7 pg/ml) than did eyes with POAG (855.0 ± 341.5 pg/ml) and ACG (759.4 ± 511.4 pg/ml) (p < 0.01). There was no effect of age, sex, or history of medical, laser, or surgical treatment of the aqueous humor HGF concentration (p > 0.05). Aqueous humor and plasma HGF concentrations were measured and compared in 28 patients. The aqueous humor HGF concentration (908 ± 586.2 pg/ml) was significantly higher (p < 0.01) than the plasma concentration (521.3 ± 183.1 pg/ml). No significant correlation could be found between aqueous humor and plasma HGF concentrations. CONCLUSIONS: The relatively high concentration of HGF in human aqueous humor suggests that HGF may play an important role in ocular physiology and disease. The higher concentration in patients with glaucoma may indicate a response to injury.

Dr D.N. Hu, Tissue Culture Centre, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA. dhu@nyec.edu

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Classification:

2.6 Aqueous humor dynamics (Part of: 2 Anatomical structures in glaucoma)

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