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Abstract #6336 Published in IGR 3-2
Scanning laser polarimetry versus frequency-doubling perimetry and conventional threshold perimetry: changes during a 12-month follow-up in preperimetry glaucoma: a pilot study
Holló G; Szabó A; Vargha PActa Ophthalmologica Scandinavica 2001; 79: 403-407
PURPOSE: To evaluate the possibility of detecting the progression in preperimetry primary open-angle glaucoma (POAG) using scanning laser polimetry (SLP), frequency-doubling technology (FDT), and conventional automated perimetry (AP). PATIENTS AND METHODS: Twenty-two eyes of 11 preperimetric POAG patients were evaluated using SLP (Nerve Fiber Analyzer, GDx), AP (Humphrey 24-2 threshold test) and FDT (30° threshold test). All eyes had intraocular pressure (IOP) higher than 21 mmHg before treatment, but were consistently lower than 22 mmHg with unchanged topical medication before and during the study. At the initial evaluation session, optic nerve heads showed mild glaucomatous changes, but the visual fields were normal (MD better than 2.0 dB, glaucoma hemifield test: within normal limits or borderline). AP and FDT measurements were repeated six months later, and all three tests were repeated 12 months after the first investigations. RESULTS: IOP, AP, and FDT measurements showed no statistically significant changes during the 12-month follow-up period. In contrast to this, a tendency for a glaucomatous type decrease was seen with SLP in the retinal nerve fiber layer (RNFL) thickness parameters (mean superior and inferior sector thickness values, ellipse average thickness, and maximum modulation). The mean decrease of RNFL thickness in the superior and inferior sectors was 2.77 and 2.48 μm, respectively. Using the two-way nested ANOVA, which considers the relationship between the right and left eyes of subjects, the decrease was statistically significant (p = 0.021) for the inferior sector RNFL thickness. CONCLUSIONS: The results suggest that SLP is a useful technique for detecting and measuring glaucomatous progression in early glaucoma. SLP of the RNFL may help to detect and quantify early progression even if worsening is not seen with perimetry and FDT tests.
Dr G. Holló, 1st Department of Ophthalmology, Semmelweis University, Budapest, Hungary
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
