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Abstract #6431 Published in IGR 3-2
Clinical and specular microscopic manifestations of iridocorneal endothelial syndrome
Liu YK; Wang IJ; Hu FR; Hung PT; Chang HWJapanese Journal of Ophthalmology 2001; 45: 281-287
PURPOSE: To investigate the correlation between the clinical pictures and specular microscopic findings in patients with iridocorneal endothelial (ICE) syndrome. METHODS: The records of 15 patients with ICE syndrome who presented at the National Taiwan University Hospital between 1993 and 1996 were examined. The medical history, clinical pictures of the cornea, iris, and anterior chamber angle, intraocular pressure (IOP), specular microscopic findings, and the correlation between clinical and specular microscopic findings were assessed. RESULTS: Endothelial changes in specular micrographs were found in all the patients, even in those patients with minimal angle involvement by peripheral anterior synechiae. Corneal decompensation resulting in corneal edema and bullae formation was the main cause of visual impairment. Neither ICE grading nor endothelial cell density correlated with corneal edema or IOP, but they correlated with the angle involvement in ICE syndrome. IOP was difficult to control in eight of these patients, even after treatment with antiglaucoma agents and trabeculectomy, especially in patients with Cogan-Reese syndrome. CONCLUSIONS: Although specular microscopy provides an invaluable method for the diagnosis of ICE syndrome, it is not a reliable tool for predicting prognosis. Close follow-up of IOP and early detection of glaucoma are important steps to preserving visual function in patients with ICE syndrome.
Dr F.R. Hu, Department of Ophthalmology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan
Classification:
9.4.2.1 Iridocorneal endothelial syndrome (ICE, incl. irisatrophy) (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.2 Glaucomas associated with disorders of the cornea, conjunctiva, sclera)
