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Abstract #6465 Published in IGR 3-2
Effect of topical brimonidine on intraocular pressure after small incision cataract surgery
Rainer G; Menapace R; Findl O; Petternel V; Kiss B; Georgopoulos MJournal of Cataract and Refractive Surgery 2001; 27: 1227-1231
PURPOSE: To evaluate the effect of brimonidine 0.2% on intraocular pressure (IOP) after small-incision cataract surgery. METHODS: This prospective randomized study comprised 80 eyes of 40 patients scheduled for small-incision cataract surgery in both eyes. In each patient, one eye was randomly assigned to receive one drop of brimonidine 0.2% or no treatment (control) immediately after surgery. The fellow eye received the other assigned treatment. All patients had standardized surgery by the same surgeon with sodium hyaluronate 1%, a temporal 3.5-mm sutureless posterior limbal incision, phacoemulsification, and implantation of a foldable intraocular lens. IOP was measured preoperatively as well as six and 20-24 hours and one week postoperatively. RESULTS: Six hours after surgery, the mean increase in IOP was 4.7 ± 6.1 mmHg (SD) in the brimonidine group and 4.6 ± 5.3 mmHg in the control group. In each group, 17 eyes (43%) had an IOP increase of 5 mmHg or more. Twenty to 24 hours after surgery, the mean increase in IOP was 1.5 ± 4.2 mmHg in the brimonidine group and 1.6 ± 4.4 mmHg in the control group. There were no statistically significant between-group differences at any measurement. CONCLUSIONS: In both groups, IOP increased significantly six hours and 20-24 hours after small-incision cataract surgery. Brimonidine 0.2% failed to reduce the IOP increase observed after small-incision cataract surgery.
Dr G. Rainer, Department of Ophthalmology, University of Vienna, Waehringer Guertel 18020, A-1090 Vienna Austria. georg.rainer@akl-wien.ac.at
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
