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Abstract #6476 Published in IGR 3-2
Intraindividual comparison of the effects of a fixed dorzolamide-timolol combination and latanoprost on intraocular pressure after small incision cataract surgery
Rainer G; Menapace R; Findl O; Petternel V; Kiss B; Georgopoulos MJournal of Cataract and Refractive Surgery 2001; 27: 706-710
PURPOSE: To compare the effect of a fixed dorzolamide-timolol combination with that of latanoprost on intraocular pressure (IOP) after small incision cataract surgery. METHODS: This prospective randomized study comprised 60 eyes of 30 patients scheduled for small incision cataract surgery in both eyes. The patients were randomly assigned to receive one drop of a fixed dorzolamide-timolol combination or latanoprost immediately after cataract surgery in the first eye. The second eye received the other antiglaucomatous agent. Cataract surgery was performed under sodium hyaluronate 1% with a temporal 3.5-mm sutureless posterior limbal incision, phacoemulsification, and implantation of a foldable intraocular lens. IOP was measured preoperatively, as well as six and 20-44 hours and one week postoperatively. RESULTS: Six hours after surgery, mean IOP decreased by -0.8 ± 3.2 mmHg (SD) (p = 0.184) in the dorzolamide-timolol group and increased by 3.6 ± 3.5 mmHg (p < 0.001) in the latanoprost group. Twenty to 24 hours after surgery, mean IOP decreased by -2.8 ± 2.4 mmHg (p < 0.001) in the dorzolamide-timolol group, and increased by 0.6 ± 3.5 mmHg (p = 0.353) in the latanoprost group. The differences between the groups were significant at six hours (p < 0.001) and 20-24 hours (p < 0.001). CONCLUSIONS: The fixed dorzolamide-timolol combination was more effective than latanoprost in reducing IOP after small incision cataract surgery. Only the fixed dorzolamide-timolol combination prevented a postoperative IOP increase and occasional IOP spikes of 30 mmHg or higher.
Dr G. Rainer, Department of Ophthalmology, University of Vienna, Vienna, Austria
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
11.4 Prostaglandins (Part of: 11 Medical treatment)
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
