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Abstract #6483 Published in IGR 3-2
Additive IOP-reducing effect of latanoprost in patients insufficiently controlled on timolol
Bron AM; Denis P; Nordmann JP; Rouland JF; Sellem E; Johansson MActa Ophthalmologica Scandinavica 2001; 79: 289-293
PURPOSE: To evaluate the effect on intraocular pressure (IOP) of switching from timolol to latanoprost or from adding latanoprost to timolol in patients with open-angle glaucoma or ocular hypertension, in whom IOP is not adequately controlled with timolol. METHODS: This was a six-week, double-masked, randomized, multi-center study. Fifty-three patients with primary open-angle glaucoma, capsular glaucoma, or ocular hypertension, with an IOP of at least 21 mmHg on current therapy, were recruited. After a run-in period of at least two weeks on timolol, 5 mg/ml twice daily, patients were randomized to one of three groups. One group continued on timolol, one switched from timolol to latanoprost, 50 μg/ml once daily, and the third group received latanoprost in addition to timolol. The efficacy was evaluated by comparing IOP at 9 a.m. at baseline and after six weeks of treatment. RESULTS: IOP at baseline and after six weeks of treatment (mean ± SEM) was 24.2 ± 0.0 and 23.8 ± 1.0 mmHg (n = 16) for patients continuing on timolol, 26. 3± 1.2 and 19.6 ± 1.1 mmHg (n = 17) for patients switching to latanoprost, and 23.2 ± 1.0 and 17.5 ± 0.8 mmHg (n = 17) for patients with the combined treatment. Adding latanoprost to timolol reduced IOP by 5.9 ± 0.9 mmHg (p < 0.001), and switching from timolol to latanoprost reduced IOP by 5.0 ± 0.9 mmHg (p < 0.001), which caused a significant reduction of IOP of about 25% in each group. CONCLUSIONS: The effect of latanoprost was additive to that of timolol, and a good effect on IOP reduction was also achieved by switching from timolol to latanoprost, suggesting that a switch in many patients is an effective alternative to combination treatment.
Dr A.M. Bron, Service Ophtalmologie, Hôpital Général, Dijon, France
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
