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Abstract #6498 Published in IGR 3-2
Effect of pilocarpine 4% in combination with latanoprost 0.005% or 8-iso prostaglandin E2 0.1 on intraocular pressure in laser-induced glaucomatous monkey eyes
Serle JB; Wang RF; Mittag TW; Shen F; Podos SMJournal of Glaucoma 2001; 10: 215-219
PURPOSE: To compare the effect of pilocarpine, an agent that reduces uveoscleral outflow, on the ocular hypotensive efficacy of latanoprost and 8-iso prostaglandin E2 (PGE2). METHODS: Each of the two treatment groups was composed of the same eight monkeys with unilateral laser-induced glaucoma. Intraocular pressure (IOP) was measured hourly for six hours beginning at 9 a.m. on the baseline day (Thursday before treatment week) and on treatment days 1, 3, and 5 (Monday, Wednesday, and Friday). On all five treatment days, one drop of pilocarpine 4% was administered at 9 a.m. and 3 p.m., and one drop of latanoprost 0.005% or 25 μl of 8-iso PGE2 0.1% was administered at 10 a.m. and 4 p.m. RESULTS: One hour after pilocarpine instillation on day 1, the reduction of IOP was similar (p > 0.90) in both treatment groups, 7.6 ± 1.1 mmHg (mean ± standard error of the mean) in the latanoprost group and 7.4 ± 0.8 mmHg in the 8-iso PGE2 group. However, the IOP effects of the two treatment groups because significantly different (p < 0.05) beginning two hours after dosing with latanoprost or 8-iso PGE2 on day 1. A difference (p < 0.05) between the two groups persisted at all subsequent measurements. The reduction of IOP lessened with repeated dosing in the latanoprost and 8-iso PGE2 groups. Three hours after dosing with pilocarpine and two hours after dosing with the prostanoids, IOP reduction was 8.3 ± 0.9 mmHg in the latanoprost group and 9.9 ± 0.6 mmHg in the 8-iso PGE2 group on day 1, and 2.1 ± 1.0 mmHg in the latanoprost group and 7.3 ± 0.9 mmHg in the 8-iso PGE2 group on day 5. CONCLUSIONS: The smaller reductions in IOP with pilocarpine and latanoprost than with pilocarpine and 8-iso PGE2 show that pilocarpine blocks much more of the ocular hypotensive effect of latanoprost than of 8-iso PGE2. The results also indicate that pilocarpine and latanoprost are mutually antagonistic. Enhancement of uveoscleral outflow appears to account for most of the ocular hypotensive effect of latanoprost and for much less of the ocular hypotensive effect of 8-iso PGE2.
Dr J.B. Serle, Box 1183, Mount Sinai School of Medicine of New York University, One Gustave L. Levy Place, New York, NY 10029, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
