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Abstract #6553 Published in IGR 3-2
Long-term results and complications of trabeculectomy augmented with low dose mitomycin C in patients at risk for filtration failure
Casson R; Rahman R; Salmon JFBritish Journal of Ophthalmology 2001; 85: 686-688
AIM: To determine the results and complications up to five years after trabeculectomy with 0.02% mitomycin C (MMC) in glaucoma patients at risk for failure of filtration surgery. METHODS: A consecutive series of 21 eyes from 20 patients who underwent trabeculectomy with MMC 0.02%, with an exposure time of two minutes, was retrospectively analyzed and the results were compared with previously published data. RESULTS: The mean preoperative intraocular pressure (IOP) was 28 mmHg on an average of 2.8 glaucoma medications, and the mean postoperative IOP after three years was 14 mmHg on an average of 0.4 medications. Three years after trabeculectomy, 17 of 21 (80.9%) eyes had an IOP of less than 21 mmHg without medical treatment. Using Kaplan-Meier life table analysis, the five-year probability of an IOP of less than 21 mmHg without medication was 67%, and with medication 90%. Two patients required further glaucoma surgery during the first postoperative year, and another developed hypotonous maculopathy which was reversed after bleb revision. Seven patients developed visually significant cataract as a late consequence of the surgery. There were no bleb-related infections. CONCLUSIONS: In the long term, MMC 0.02% used for two minutes intraoperatively is an effective adjunctive treatment in glaucoma patients at risk for bleb failure, and this dose is associated with few complications.
Mr J. Salmon, Oxford Eye Hospital, Woodstock Road, Oxford OX2 6HE, UK. john.salmon@orh.nhs.uk
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
