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Abstract #6561 Published in IGR 3-2
Intraoperative mitomycin-C without conjunctival and Tenon's capsule touch in primary trabeculectomy
Susanna R Jr; Costs VP; Malta RFS; Barboza WL; Vasconcellos JPCOphthalmology 2001; 108: 1039-1042
OBJECTIVE: To verify whether intraoperative mitomycin C (MMC) without conjunctival and Tenon's touch is effective in inhibiting the development of thin, avascular blebs in eyes undergoing primary trabeculectomy. DESIGN: A noncomparative, interventional study. PARTICIPANTS: Fifteen eyes of 15 consecutive patients undergoing primary trabeculectomy. INTERVENTION: All eyes underwent trabeculectomy with intraoperative MMC (0.25 mg/ml for three minutes) with either conjunctival or Tenon's touch. Patients were examined one, three, six, and 12 months after surgery. Intraocular pressure (IOP) and number of medications were evaluated at each examination. The appearance of the bleb was classified at the last examination into one of three groups: flat and vascularized; elevated but not avascular; or elevated, thin, and avascular. MAIN OUTCOME MEASURES: IOP, number of antiglaucoma medications, and appearance of the bleb. RESULTS: Preoperative mean IOP was 30.57 ± 10.92 mmHg. Statistically significant IOP reductions were observed one, three, six and 12 months after surgery (p < 0.01). Twelve months after surgery, the mean IOP was 14.92 ± 6.53 mmHg. Five eyes (33.3%) showed an IOP of less than 15 mmHg without antiglaucoma medication at the 12-month examination. The bleb was considered elevated, thin, and avascular in 12 of 15 eyes (80%) at the end of follow-up. CONCLUSIONS. Intraoperative MMC at 0.25 mg/ml for three minutes with either conjunctival or Tenon's touch was not effective in eliminating the development of thin, avascular blebs in eyes undergoing primary trabeculectomy.
Dr R. Susanna Jr, Glaucoma Service, University of Sao Paulo, Av. Sao Gualter 99, Sao Paulo 05400-000, Brazil. rsusanna@originet.com.br
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
