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Abstract #65845 Published in IGR 17-3
Phase-contrast Micro-computed Tomography Measurements of the Intraocular Pressure-induced Deformation of the Porcine Lamina Cribrosa
Coudrillier B; Geraldes D; Vo N; Atwood R; Reinhard C; Campbell I; Raji Y; Albon J; Abel R; Ethier RIEEE Transactions on Medical Imaging 2016; 35: 988-999
See also comment(s) by Andrew Tatham •
The lamina cribrosa (LC) is a complex mesh-like tissue in the posterior eye. Its biomechanical environment is thought to play a major role in glaucoma, the second most common cause of blindness. Due to its small size and relative inaccessibility, highresolution measurements of LC deformation, important in characterizing LC biomechanics, are challenging. Here we present a novel noninvasive imaging method, which enables measurement of the three-dimensional deformation of the LC caused by acute elevation of intraocular pressure (IOP). Posterior segments of porcine eyes were imaged using synchrotron radiation phase contrast micro-computed tomography (PC CT) at IOPs between 6 and 37mmHg. The complex trabecular architecture of the LC was reconstructed with an isotropic spatial resolution of 3.2 m. Scans acquired at different IOPs were analyzed with digital volume correlation (DVC) to compute full-field deformation within the LC. IOP elevation caused substantial tensile, shearing and compressive deformation within the LC, with maximum tensile strains at 30mmHg averaging 5.5%, and compressive strains reaching 20%. We conclude that PC CT provides a novel high-resolution method for imaging the LC, and when combined with DVC, allows for full-field 3D measurement of ex vivo LC biomechanics at high spatial resolution.
Full article
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
