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Abstract #65972 Published in IGR 17-3

Persistence of Glaucoma Therapy and Visual Field Progression

De Leon JM; Quek DT; Htoon HM; Tun TA; Perera SA; Lamoureux EL; Aung T
Journal of Glaucoma 2016; 25: e336-e339

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PURPOSE: To determine the association of visual field (VF) progression with medication persistence in a cohort on glaucoma therapy. PATIENTS AND METHODS: Pharmacy records were examined over 3 years for patients started on glaucoma monotherapy. A patient was persistent if a prescription was refilled for the same medication <90 days after the previous prescription had lapsed; otherwise was nonpersistent. Only patients with >5 reliable VFs within 1-year pretherapy and 6-year posttherapy were included. Progression was analyzed with pointwise linear regression and defined using 2 criteria: (A) ≥2 adjacent progressing points (slope P<0.01) in 1 hemifield; and (B) ≥3 progressing points (slope P<0.01). The mean number and mean slope of progressing points and the mean global slopes were determined. RESULTS: Of 1206 patient eyes (131 persistent, 1075 nonpersistent), 941 were excluded leaving 175 (47 persistent and 128 nonpersistent) for analysis. The mean follow-up durations were 59.3±10.9 and 58.2±9.7 months (P=0.07) for persistent and nonpersistent eyes, respectively. Overall, 2/47 (4.3%) and 10/128 (7.8%) eyes progressed among persistent and nonpersistent patients, respectively (P=0.52) using criterion A and 1/47 (2.1%) and 12/128 (9.4%; P=0.19) eyes using criterion B. Mean number of progressing points (0.3±0.9 vs. 0.7±1.8; P=0.17), mean slope of progressing points (-2.2±1.1 vs. -2.8±1.3 dB/y; P=0.27), and mean global slope (0.7±0.5 vs. -0.1±0.8 dB/y; P=0.07) were similar for persistent and nonpersistent patients, respectively. CONCLUSION: There were small but appreciable differences in VF progression rates between persistent and nonpersistent patient eyes on glaucoma drops, but differences were not significant.

*Singapore and Singapore National Eye Centre, Singapore Eye Research Institute ‡Duke-NUS Medical School §Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore †Cardinal Santos Medical Center, San Juan City, Metro Manila, Philippines.

Full article

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Classification:

11.17 Cooperation with medical therapy e.g. persistency, compliance, adherence (Part of: 11 Medical treatment)
6.20 Progression (Part of: 6 Clinical examination methods)

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