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Abstract #6624 Published in IGR 4-1
Endothelin 1 levels in the aqueous humor of dogs with glaucoma
Kallberg ME; Brooks DE; Garcia-Sanchez GA; Komaromy AM; Szabo NJJournal of Glaucoma 2002; 11: 105-109
PURPOSE: Endothelin 1 is a small peptide that is involved in regulation of intraocular pressure (IOP) and modulation of ocular circulation. To investigate the role of endothelin 1 in canine glaucoma, the authors measured aqueous humor levels of endothelin 1 in healthy dogs and in dogs with hypertensive glaucoma. METHODS: Aqueous humor samples were obtained with general anesthesia from the eyes of healthy dogs (n = 5) and dogs with hypertensive glaucoma (n = 10). Measurements were made by enzyme immunoassay for endothelin 1. RESULTS: The endothelin 1 aqueous humor range was 1.12-3.63 pg/ml for healthy dogs and 1.97-14.97 pg/ml for glaucomatous dogs. The healthy and glaucomatous canine endothelin 1 aqueous levels (mean ± SD) were 2.33 ± 0.90 and 8.11 ± 5.03 pg/ml, respectively. A two-way analysis of variance indicated that this difference was significant (p = 0.0084). The effect of age on endothelin 1 levels was not significant (p = 0.6283). The large variability found within the glaucomatous group could be explained by the degree of damage of the retina (p = 0.0006). There was no significant correlation between IOP and endothelin 1 aqueous humor levels within the glaucomatous group (p = 0.29). CONCLUSIONS: The aqueous humor of dogs with hypertensive glaucoma contains significantly higher levels of endothelin 1 than that of healthy dogs.
Dr. M.E. Kallberg, Small Animal Clinical Sciences, College of Veterinary Medicine, and Department of Statistics, College of Medicine, University of Florida, Gainesville, FL, USA
Classification:
2.6 Aqueous humor dynamics (Part of: 2 Anatomical structures in glaucoma)
