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Abstract #6679 Published in IGR 4-1
3α,5β-tetrahydrocortisol effect on outflow facility
Seeman J; Hubbard WC; Gabelt BT; Kaufman PKJournal of Ocular Pharmacology and Therapeutics 2002; 18: 35-39
3α,5β-tetrahydrocortisol (THF) was administered topically and intracamerally to ocular normotensive cynomolgus monkeys to determine whether it affects outflow facility. Monkeys received THF either topically at a dose of 2 x 5 μl drops of 300 μg/10 μl twice daily for four days (n = 4) or three times daily for ten days (n = 4) with 10% DMSO as vehicle to the control eye, or intracamerally via 2 ml anterior chamber (AC) exchange of 30 μg/ml THF with vehicle, 0.1% DMSO, to the control eye followed by a second AC exchange using 300 μg/ml THF with vehicle to the control eye. Outflow facility was measured by a two-level constant pressure AC perfusion after administration of eye drops or after baseline outflow facility measurement and AC exchange with THF solution. The results showed no effect on outflow facility in normotensive cynomolgus monkeys.
Dr. J. Seeman, Department of Ophthalmology, University of Wisconsin Medical School, F4/319, 600 Highland Avenue, Madison, WI 53792, USA
Classification:
5 Experimental glaucoma; animal models
6.2 Tonography, aqueous flow measurement (see also 2.6) (Part of: 6 Clinical examination methods)