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Miscellaneous (25)

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Abstract #67178 Published in IGR 17-4

Retinal ganglion cell death in glaucoma: Exploring the role of neuroinflammation

Russo R; Varano GP; Adornetto A; Nucci C; Corasaniti MT; Bagetta G; Morrone LA
European Journal of Pharmacology 2016; 787: 134-142

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In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells occurs by apoptosis. This final event is preceded by inflammatory responses involving the activation of innate and adaptive immunity, with retinal and optic nerve resident glial cells acting as major players. Here we review the current literature on the role of neuroinflammation in neurodegeneration, focusing on the inflammatory molecular mechanisms involved in the pathogenesis and progression of the optic neuropathy.

Department of Pharmacy, Nutritional and Health Sciences, University of Calabria, Arcavacata di Rende, Italy. Electronic address: rossella.russo@unical.it.

Full article

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Classification:

3.6 Cellular biology (Part of: 3 Laboratory methods)
11.8 Neuroprotection (Part of: 11 Medical treatment)

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