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Abstract #67179 Published in IGR 17-4
Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases
Li F; Wen X; Zhang H; Fan XInternational journal of molecular sciences 2016; 17:
Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), diabeticretinopathy (DR), and ocular tumors. We intend to highlight comprehensive studies that provide detailed data about the mechanisms of lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. Although our understanding of lncRNAs is still in its infancy, these examples may provide helpful insights into the methods by which lncRNAs interfere with ocular diseases.
Department of Ophthalmology, Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China. lifangniuniu@126.com.
Full articleClassification:
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)