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Abstract #67218 Published in IGR 17-4
The prognostic value of retinal vessel analysis in primary open-angle glaucoma
Waldmann NP; Kochkorov A; Polunina A; Orgül S; Gugleta KActa Ophthalmologica 2016; 94: e474-e480
PURPOSE: To analyse a prognostic value of initial retinal vessel flicker response for the 3-year development of functional (visual field) and morphological (nerve fibre layer thickness) damage progression in primary open-angle glaucoma patients. PATIENTS AND METHODS: Initially, 70 patients were recruited, and flicker response was measured by standardized procedure with the retinal vessel analyser (RVA). Ocular coherence tomography of retinal nerve fibre layer (OCT RNFL) and a visual field testing were performed at beginning and every 6 months for 3 years; 56 patients completed the study. RESULTS: No correlation was found between the progression of visual field (VF) mean defect and retinal nerve fibre layer (RNFL) thinning over 3 years on one and the maximal flicker reaction in arteries and veins on the other side (all p > 0.1). However, the calculated difference of examined parameters in the superior versus inferior retinal halves correlated significantly between the RNFL thinning and the initial maximal flicker response for arteries (p = 0.01) and veins (p = 0.003). CONCLUSION: This longitudinal study did not find a general correlation between initial retinal vessel response to flicker light and the glaucoma damage progression measured by OCT and VF, hence limiting the relevance of the RVA device as a predictor of future glaucomatous damage.
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)