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Abstract #6836 Published in IGR 4-1
Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus
Makimoto Y; Sugiyama T; Kojima S; Azuma IJapanese Journal of Ophthalmology 2002; 46: 31-35
PURPOSE: To investigate the long-term effect of 0.12% isopropyl unoprostone (Rescula®) on the microcirculation of the human ocular fundus. METHODS: A laser speckle tissue circulation analyzer was used to measure normalized blur (NB), a quantitative index of blood flow velocity, in the optic nerve head (ONH) and choroid-retina before and 4.5 hours after the instillation of a placebo into both eyes of 11 healthy volunteers. Intraocular pressure (IOP), blood pressure, and pulse rate were also recorded in this control experiment. Thereafter, a drop of unoprostone or a placebo was instilled into each eye in a double-blind manner twice a day for 21 days to form treated and untreated groups. RESULTS: After 21 days, the NB values in the ONH and choroid-retina had increased significantly and IOP had decreased significantly in the unoprostone-treated eyes. Ocular perfusion pressure showed no significant change. CONCLUSION: These results suggest that long-term application of unoprostone can increase microcirculatory blood flow in the human ocular fundus, probably due to a reduction in vascular resistance.
Dr. Y. Makimoto, Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-shi, Osaka 569-8686, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
