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Abstract #6855 Published in IGR 4-1
Experimental researches of ocular hypertension retinal injury and the NOS mechanism in the injury
Yang X; Li JChinese Ophthalmic Research 2002; 20: 39-42
OBJECTIVES: (1) To observe the expression of NOS in the retina; (2) to investigate the function of the NOS inhibitor L-NAME (N<sup>G</sup>-nitro-L-arginine ester) in ischemia reperfusion of ocular hypertension. METHODS: The authors examined the expression of nNOS, eNOS, and iNOS in retinal ocular hypertension ischemia and reperfusion, and the affect of NOS inhibitor L-NAME on the expression using the immunohistochemistry SABC method. RESULTS: 1. nNOS, eNOS, and iNOS positive expression could be examined in retinal ganglion and neuroglial cells in ischemia reperfusion of ocular hypertension. nNOS was weakly positive in the normal control group. 2. After L-NAME injection, only iNOS was positive in the retinal ganglion and neuroglial cells, while nNOS and eNOS were negative in ischemia reperfusion of ocular hypertension. CONCLUSIONS: 1. NOS plays some cytotoxicity roles in the retina. 2. By inhibiting the activity of nNOS and eNOS, L-NAME may protect the retina against ischemia reperfusion injury.
Dr X. Yang, Department of Ophthalmology, Tang-Du Hospital, Fourth Military Medical University, Xi'an 710038, China
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
