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Abstract #6884 Published in IGR 4-1
Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma
Galassi F; Sodi A; Renieri G; Ucci F; Pieri B; Harris A; Siesky BOphthalmologica 2002; 216: 123-128
The authors considered a group of patients with newly diagnosed primary open-angle glaucoma by studying the effects of four-week treatment with timolol or dorzolamide on the retrobulbar vessels. Ocular hemodynamics were assessed by means of color Doppler imaging of the ophthalmic artery, the temporal short posterior ciliary arteries (SPCAs), and the central retinal artery. For each vessel, systolic and diastolic blood flow velocities were measured, and the resistivity index (RI) calculated. The only significant result was a reduction of temporal SPCA RI after dorzolamide treatment in comparison with baseline (p = 0.011). In the same group, dorzolamide treatment had a slight and nonsignificant increase in temporal SPCA diastolic velocity. The resistance decrease observed after dorzolamide treatment in the ciliary circulation may be due to the decrease in intraocular pressure or a possible direct vasodilating effect of the drug.
Dr. F. Galassi, Department of Oto-Neuro-Ophthalmological Surgery, Section of Ophthalmology, University of Florence, Italy
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
