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Abstract #6885 Published in IGR 4-1
Timolol maleate 0.5% versus timolol maleate in gel forming solution 0.5% (Timolol GFS) in open angle glaucoma in India: preliminary safety and efficacy study
Kumar H; Sudan R; Sethi HS; Sony PIndian Journal of Ophthalmology 2002; 50: 21-23
PURPOSE: To compare the efficacy and safety profile of Timolol maleate 0.5% versus Timolol gel forming solution (GFS) 0.5% in open-angle glaucoma in Indian eyes. METHODS: In a prospective crossover study, 52 open-angle glaucoma patients with well-controlled intraocular pressure (IOP) on 0.5% timolol maleate solution were switched over to timolol GFS once a day, after a washout period of one month. Diurnal IOP was measured after six weeks and compared with patients on timolol maleate 0.5% twice a day. In addition, side-effects reported or observed were compared. RESULTS: No statistically significant difference was observed in the ocular hypotensive effects of the two treatments. The side-effects of both treatment groups were similar, except for a higher incidence of blurring of vision in patients on timolol GFS. Compliance was better with timolol GFS, but was not statistically significant. CONCLUSIONS: The results of this study suggest that the more convenient 0.5% timolol in gel forming solution can be offered as an equally efficacious and well-tolerated alternative to twice daily 0.5% timolol solution in open-angle glaucoma.
Dr. R. Sudan, All India Institute of Medical Sciences, Hostel No. 7, Ansari Nagar, New Delhi-110 029, India. rsudan2O@yahoo.com
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
