advertisement
Abstract #6888 Published in IGR 4-1
Effect of topical betaxolol on the acute rise of aqueous flare induced by highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits
Yanagisawa S; Hayasaka S; Zhang XY; Hayasaka Y; Nagaki Y; Kitagawa KOphthalmic Research 2002; 34: 48-50
PURPOSE: To evaluate the role of topical betaxolol on experimental ocular inflammation in rabbits. METHODS: Transcorneal diffusion of highly selective agonists for prostaglandin E2 receptor subtypes (EP), 25 μg/ml, with the use of a glass cylinder, was performed to produce aqueous flare elevation in pigmented rabbits. Betaxolol was topically administered before EP agonist application. Aqueous flare was measured with a laser flare cell meter. RESULTS: Performing topical instillation of 0.5% betaxolol four times inhibited 52 ± 9% of EP2-agonist (ONO-AE1-259-01)-induced aqueous flare elevation. The inhibition of flare elevation was dependent on the number of betaxolol instillations. Betaxolol did not suppress the elevation induced by an EP4 agonist (ONO-AE1-392). CONCLUSION: Betaxolol inhibited EP2-agonist-induced aqueous flare elevation in pigmented rabbits.
Dr. S. Yanagisawa, Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
