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Abstract #68998 Published in IGR 18-1
Human TBK1: A Gatekeeper of Neuroinflammation
Ahmad L; Zhang SY; Casanova JL; Sancho-Shimizu VTrends in molecular medicine 2016; 22: 511-527
The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that modulates inflammation and autophagy, in human health has been highlighted for the first time by the recent discoveries of mutations in TBK1 that underlie amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE). Gain-of-function of TBK1 are associated with NTG, whereas loss-of-function mutations result in ALS/FTD or in HSE. In light of these new findings, we review the role of TBK1 in these seemingly unrelated, yet allelic diseases, and discuss the role of TBK1 in neuroinflammatory diseases. This discovery has the potential to significantly increase our understanding of the molecular basis of these poorly understood diseases.
Department of Virology, Division of Medicine, Imperial College London, Norfolk Place, London W2 1 PG, UK.
Full articleClassification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)