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Abstract #69168 Published in IGR 18-1

Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure-Function Relationship in Glaucoma

Fujino Y; Yamashita T; Murata H; Asaoka R
Investigative Ophthalmology and Visual Science 2016; 57: 3152-3158

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PURPOSE: To investigate whether correcting the circumpapillary retinal nerve fiber layer (cpRNFL) thickness profile, using retinal artery position and papillomacular bundle tilt, can improve the structure-function relationship in glaucoma patients. METHODS: Spectral-domain optical coherence tomography (SD-OCT) and visual field measurements were conducted in 142 eyes of 90 subjects with open angle glaucoma. The SD-OCT cpRNFL thickness profile was corrected for retinal artery position and/or papillomacular tilt in all twelve 30° sectors of the optic disc, and the structure-function relationship against corresponding 30° sectorial retinal sensitivity was investigated by using linear mixed model. RESULTS: Applying a correction to the cpRNFL thickness profile for retinal artery position resulted in a stronger structure-function relationship in all 12 sectors of the optic disc. Furthermore, applying a further adjustment for papillomacular tilt resulted in a further improvement in 9 of 12 sectors. CONCLUSIONS: Correcting cpRNFL profile, using the retinal artery position significantly strengthened the structure-function relationship. In most optic disc sectors, using the papillomacular bundle tilt improved cpRNFL thickness measurements.

Department of Ophthalmology The University of Tokyo, Tokyo, Japan.

Full article

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Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)

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