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Abstract #6922 Published in IGR 4-1
Effects of tranilast on filtering blebs: a pilot study
Chihara E; Dong J; Ochiai H; Hamada SJournal of Glaucoma 2002; 11: 127-133
PURPOSE: To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. PATIENTS AND METHODS: This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randomly assigned to receive either 0.5% tranilast eye drops (24 eyes) or vehicle saline solution (28 eyes) four times daily for three months after trabeculectomy. Features of the bleb, such as vascularization and size, and IOP were studied. RESULTS: The incidence of vascularized bleb and 'pseudopod' formation six months post-treatment were more common in tranilast-treated eyes than control eyes (p = 0.019 and p = 0.043, respectively). The bleb was significantly larger at six and 12 months (p = 0.024 and p = 0.049, respectively), and reduction of IOP was more significant at two years postoperatively (p = 0.002 to p = 0.032) in tranilast-treated eyes than control eyes. No vision-threatening side-effects were associated with tranilast. CONCLUSIONS: The use of topical tranilast after filtering surgery alleviates ischemia of the filtering bleb, reduces IOP, and increases the size of the bleb.
Dr. E. Chihara, Sensho-kai Eye Institute, Kyoto, Japan;
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)