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Abstract #70350 Published in IGR 18-2
Retinal nerve fibre layer thickness in a general population in Iran
Hashemi H; Khabazkhoob M; Nabovati P; Yekta A; Emamian MH; Fotouhi AClinical and Experimental Ophthalmology 2017; 45: 261-269
BACKGROUND: To determine retinal nerve fibre layer (RNFL) thickness distribution and its related factors in a general population of 45 to 69 year olds in Iran. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Of the 5190 participants of phase one of Shahroud Eye Cohort Study, 4737 participated in Phase two (participation rate = 91.3%). METHODS: All study participants underwent visual acuity measurement, refraction tests, slit lamp examination and ophthalmoscopic fundus exam. Tests also included imaging with Cirrus HD-OCT 4000 and its RNFL thickness data were used in this study. MAIN OUTCOME MEASURES: The overall RNFL thickness and the average RNFL thickness in different quadrants. RESULTS: Mean RNFL thickness in the superior, inferior, nasal and temporal quadrants were 92.47 µm [95% confidence interval (CI): 92.14-92.80], 111.22 µm (95% CI: 110.7-111.73), 118.93 µm (95% CI: 118.31-119.55), 74.83 µm (95% CI: 74.07-75.59) and 65.48 µm (95% CI: 65.06-65.90). Multiple linear regression models indicated that RNFL thickness in all quadrants decreased with ageing, was lower in females (coefficient:-0.87 and P = 0.015), decreased by 1.42 µm (P < 0.001) for each millimetre increase in axial length and decreased by 0.41 µm (P = 0.041) for each diopter decrease in spherical equivalent refraction of myopia. CONCLUSION: RNFL thickness in the 45 to 69-year-old Iranian population is lower compared to other studies. This difference should be noted in making disease diagnoses, particularly glaucoma. Also, there is a significant relationship between ageing and RNFL thinning in all quadrants. Longer axial length, myopia and male gender are associated with reduced RNFL thickness.
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)