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Abstract #71197 Published in IGR 18-3

Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography

Srinivas S; Dastiridou A; Durbin MK; Nittala MG; Huang AA; Tan JC; Francis BA; Sadda SR; Chopra V
Journal of Glaucoma 2017; 26: 138-143

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PURPOSE: To compare the lamina cribrosa (LC) intensity in glaucoma-suspect eyes and eyes with mild to moderate glaucoma using swept-source optical coherence tomography. METHODS: Optic disc volume scans were collected using swept-source optical coherence tomography in 19 clinically defined glaucoma-suspect eyes and 29 eyes with mild to moderate glaucoma. LC intensity was measured using Image J software, and the resultant values were normalized using the retinal pigment epithelium and vitreous signal. RESULTS: Mean age was 53.7±18.5 years in the glaucoma-suspect eyes and 63.0±16.1 years in the eyes with mild to moderate glaucoma (P=0.161). Significant differences in LC intensity were observed between the 2 groups, with median LC intensity values of 0.96 and 0.86 units in the glaucoma-suspect and the mild to moderate glaucoma groups, respectively (P<0.001). A weak positive correlation was found between mean deviation and normalized LC intensity (r=0.344; P=0.018). CONCLUSIONS: Intensity measurement of the LC is a potential novel parameter which warrants further study in the setting of glaucoma.

*Doheny Image Reading Center, Doheny Eye Institute ‡Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles †Carl Zeiss Meditec Inc., Dublin, CA.

Full article

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Classification:

2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)

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