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Abstract #71305 Published in IGR 18-3
Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: a hypothesis
Kountouras J; Boziki M; Polyzos SA; Katsinelos P; Gavalas E; Zeglinas C; Tzivras D; Romiopoulos I; Giorgakis N; Anastasiadou K; Vardaka E; Kountouras C; Kazakos E; Xiromerisiou G; Dardiotis E; Deretzi GFree radical research 2017; 51: 73-79
Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Helicobacter pylori infection is also associated with variety of systemic extragastric diseases in which H. pylori-related ROS production might also be involved in the pathogenesis of these systemic conditions. We proposed that Hp-related ROS may play a crucial role in the pathophysiology of Hp-related systemic diseases including Alzheimer's disease, multiple sclerosis, glaucoma and other relative neurodegenerative diseases, thereby suggesting introduction of relative ROS scavengers as therapeutic strategies against these diseases which are among the leading causes of disability and are associated with a large public health global burden. Moreover, we postulated that H. pylori-related ROS might also be involved in the pathogenesis of extragastric common malignancies, thereby suggesting that H. pylori eradication might inhibit the development or delay the progression of aforementioned diseases. However, large-scale future studies are warranted to elucidate the proposed pathophysiological mechanisms, including H. pylori-related ROS, involved in H. pylori-associated systemic and malignant conditions.
a Department of Medicine , Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital , Thessaloniki , Greece.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
3.9 Pathophysiology (Part of: 3 Laboratory methods)
