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Abstract #71314 Published in IGR 18-3
Longitudinal cohort study on the incidence of primary open-angle glaucoma in Bai Chinese
Pan CW; Yang WY; Hu DN; Xu JG; Niu ZQ; Yuan YS; Yu MB; Zhong HAmerican Journal of Ophthalmology 2017; 176: 127-133
PURPOSE: The prevalence of primary open-angle glaucoma (POAG) in China has been reported previously, which was lower than that in the white and black. However, the incidence of POAG in China has not been reported. Therefore, a longitudinal study was conducted to determine the 5-year cumulative incidence and predictors of POAG in China DESIGN: Population-based cohort study METHODS: Fifteen hundred and twenty participants (71.3%) of Bai ethnicity were examined and followed for 5 years. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology Classification criteria. Multivariable logistic regression models were fitted to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: A total of 19 new cases of POAG were detected. The 5-year cumulative incidence of POAG was 1.3% (95% CI, 0.7-1.9). In multivariate analyses, incident POAG was associated baseline variables including increased age (OR, 4.3; 95% CI, 1.4-13.8; P = 0.02; 70 years or older vs. 50-59 years), elevated IOP (OR, 3.5; 95% CI, 2.0-5.9; P < 0.001; per 10 mmHg increase), lower education level (OR, 0.3; 95% CI, 0.1-0.8; P = 0.02; post primary vs. no formal education) and the presence of myopia (OR, 3.4; 95% CI, 1.3-8.6; P < 0.01). CONCLUSIONS: The average annual incidence of POAG in Bai Chinese was lower than that in populations of African-descent and White. The results are important to elucidate the racial/ethnic difference in POAG incidence and for the clinical management and health resource allocation in China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China.
Full articleClassification:
1.1 Epidemiology (Part of: 1 General aspects)
