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Abstract #71561 Published in IGR 18-3
Radial Peripapillary Capillary Density Measurement Using Optical Coherence Tomography Angiography in Early Glaucoma
Mansoori T; Sivaswamy J; Gamalapati JS; Balakrishna NJournal of Glaucoma 2017; 26: 438-443
PURPOSE: The purpose of the study was to compare radial peripapillary capillary (RPC) density between normal subjects and patients with early primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCT-A). MATERIALS AND METHODS: A total of 24 patients with early POAG and age-matched 52 normal subjects underwent scanning with OCT-A imaging (RTVue XR-100, Avanti OCT). The enface angioflow images obtained were analyzed qualitatively for the RPC network, and RPC capillary density (CD) was measured in 8 sectors within a 3.45-mm-diameter circle around the optic disc, using the Bar-Selective Combination of Shifted Filter Responses (B-COSFIRE) method. CD and retinal nerve fiber layer (RNFL) thickness were compared between corresponding sectors with the Mann-Whitney U test. Correlations between CD and Humphrey visual field parameters and optic disc structural parameters were calculated by linear regression analysis. RESULTS: In the normal eyes, RPC bed was clearly visible on OCT-A as a dense microvascular network around the optic disc, whereas in POAG patients it was focally attenuated. RPC CD was lower in the inferotemporal (P=0.002) and superotemporal (P=0.008) sectors with corresponding focal RNFL defect in POAG patients when compared with normal controls. The average CD correlated with visual field mean deviation (P=0.01) and pattern standard deviation (P=0.02) in glaucomatous eyes. CONCLUSIONS: OCT-A demonstrated reproducible, focal loss of RPCs in patients with early POAG when compared with normal controls. The results of our study suggest that the RPC density measurements may have a value in the diagnosis and monitoring of glaucoma.
*Anand Eye Institute †International Institute of Information Technology ‡National Institute of Nutrition, Hyderabad, Telangana, India.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
