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Abstract #71615 Published in IGR 18-3
Peripapillary choroidal vascular layers: the Beijing Eye Study
Xu J; Wang YX; Jiang R; Wei WB; Xu L; Jonas JBActa Ophthalmologica 2017; 95: 619-628
PURPOSE: To assess thickness and associations of the peripapillary choroidal layers. METHODS: The population-based Beijing Eye Study included 3468 participants with an age of 50+ years. Using spectral-domain optical coherence tomography, we measured the large vessel layer (LVL) and small-to-medium vessel layer (SMVL) of the peripapillary choroid in a circular scan with a diameter of 3.4 mm around the optic nerve head centre at eight locations equidistant (45°) to each other. The ratio of SMVL thickness to LVL thickness was calculated. RESULTS: Measurements were available for 3000 (86.5%) study participants (mean age: 64.4 ± 9.6 years; range: 50-93 years). SMVL (mean thickness: 31 ± 7 μm; range: 17-70 μm) and LVL (103 ± 48 μm; range: 9-313 μm) were thickest superiorly, followed by the temporal region, nasal region, and inferior region. Thicker SMVL was associated (regression coefficient r: 0.33) with younger age (p < 0.001; standardized regression coefficient β: -0.26), higher cognitive function (p = 0.02; β: 0.05), shorter axial length (p < 0.001; β: -0.12), thicker lens (p < 0.001; β: 0.07), smaller disc area (p < 0.001; β: -0.08), smaller parapapillary β/γ zone (p < 0.001; β: -0.10) and lower prevalence of angle-closure glaucoma (p = 0.04; β: -0.04). Thicker LVL thickness was correlated (r: 0.45) with younger age (p < 0.001; β: -0.34) and higher cognitive function (p = 0.01; β: 0.05), shorter axial length (p < 0.001; β: -0.09)), thicker lens (p = 0.009; β: 0.06), smaller disc area (p < 0.001; β: -0.09), smaller parapapillary alpha zone (p = 0.04; β: -0.04), smaller β/γ zone (p < 0.001; β: -0.14) and lower prevalence of angle-closure glaucoma (p = 0.057; β: -0.04). A higher SMVL-to-LVL thickness ratio was related with older age (p < 0.001; β: 0.36), longer axial length (p < 0.001; β: 0.09), lower best-corrected visual acuity (BCVA) (p = 0.002; β: 0.07), larger optic disc area (p < 0.001; β: 0.10) and larger β/γ zone (p < 0.001; β: 0.19). CONCLUSION: Small-to-medium vessel layer (SMVL) and LVL, thickest superiorly and thinnest inferiorly, increased with younger age and higher cognitive function after adjusting for axial length and prevalence of angle-closure glaucoma. With older age, longer axial length, larger optic disc area and larger β zone, LVL decreased more than SMVL in thickness. The association between thicker peripapillary choroidal thickness and better cognitive function may deserve further attention.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.
Full articleClassification:
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
9.3.2 Chronic primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
