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Abstract #71643 Published in IGR 18-3

Cytokine biomarkers in tear film for primary open-angle glaucoma

Gupta D; Wen JC; Huebner JL; Stinnett S; Kraus VB; Tseng HC; Walsh M
Clinical Ophthalmology 2017; 11: 411-416

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PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα). RESULTS: Mean concentrations of tear film cytokines were lower in the glaucoma group for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL in POAG; P=0.035) was significantly lower in the tear film of patients with newly diagnosed POAG. CONCLUSION: Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early POAG.

Department of Ophthalmology, Duke University Medical Center, Durham, NC.

Full article

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Classification:

2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
3.10 Immunobiology (Part of: 3 Laboratory methods)

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