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Abstract #72778 Published in IGR 18-4
Patterns of glaucoma progression in retinal nerve fiber and macular ganglion cell-inner plexiform layer in spectral-domain optical coherence tomography
Kim HJ; Jeoung JW; Yoo BW; Kim HC; Park KHJapanese Journal of Ophthalmology 2017; 61: 324-333
PURPOSE: To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma. METHODS: One hundred-fourteen eyes of open-angle glaucoma patients with localized RNFL defect who had 3 years' worth of annual RNFL photography and OCT measurements were enrolled in this retrospective study. The progression rates of serial RNFL and GCIPL thicknesses (µm), angular width (°) and area (mm(2)) of defect on RNFL and GCIPL deviation maps were determined by linear mixed-effect models. RESULTS: Over a mean follow-up period of 3.16 years, 50 patients out of a total of 114 patients were classified as progressors based on the structural evaluation. The progressors showed significantly higher progression rates in average, 6 and 11 o'clock sector RNFL thicknesses, angular width and area of defect in RNFL deviation map, as well as inferotemporal and minimum GCIPL thicknesses than the non-progressors. The thicknesses of the 6 o'clock sector RNFL and minimum GCIPL exhibited the highest reduction rates among the RNFL and GCIPL parameters assessed, respectively. CONCLUSIONS: When evaluating glaucoma progression by OCT, careful observation of the average, 6 and 11 o'clock sectors in RNFL and inferotemporal and minimum GCIPL thicknesses can be helpful. We can effectively assess early changes of glaucoma progression with GCIPL thickness as well as RNFL thickness.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
