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Abstract #72829 Published in IGR 18-4
Receptor of Advanced Glycation End Products Gene Polymorphism and Primary Open-Angle Glaucoma
Moschos MM; Chatziralli I; Sioziou A; Gazouli MOphthalmic Research 2017; 58: 81-84
PURPOSE: The purpose of this study was to investigate the potential association between primary open-angle glaucoma and receptor of advanced glycation end products (AGER) polymorphisms in a Greek population. METHODS: This is a case-control study of 106 patients with primary open-angle glaucoma and 120 healthy control subjects of Greek origin surveyed for AGER polymorphisms (rs1051993 and rs2070600) and a potential correlation to primary open-angle glaucoma. RESULTS: AGER polymorphisms showed no statistically significant difference between patients with primary open-angle glaucoma and healthy controls. CONCLUSIONS: Our study did not find any significant association between AGER polymorphism and primary open-angle glaucoma. Since we cannot reject the possibility that oxidative stress is a crucial factor for the development of primary open-angle glaucoma, further studies may be needed to confirm the importance of the AGER gene in the glaucoma pathogenesis.
Electrophysiology Laboratory, 1st Department of Ophthalmology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Full articleClassification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)
3.7 Biochemistry (Part of: 3 Laboratory methods)
3.9 Pathophysiology (Part of: 3 Laboratory methods)