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Abstract #72947 Published in IGR 18-4

Topography and correlation of radial peripapillary capillary density network with retinal nerve fibre layer thickness

Mansoori T; Sivaswamy J; Gamalapati JS; Balakrishna N
International Ophthalmology 2018; 38: 967-974

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PURPOSE: To analyse the expansion of radial peripapillary capillary (RPC) network with optical coherence tomography angiography (OCT-A) in normal human eyes and correlate RPC density with retinal nerve fibre layer thickness (RNFLT) at various distances from the optic nerve head (ONH) edge. METHODS: Fifty eyes of 50 healthy subjects underwent imaging with RTVue XR-100 Avanti OCT. OCT-A scans of Angio disc (6 × 6 mm) and Angio retina (8 × 8 mm) were combined to create a wide-field montage image of the RPC network. RPC density and RNFLT was calculated at different circle diameter around the ONH, and their correlation was measured. RESULTS: In the arcuate region, RPC was detected as far as 8.5 mm from the ONH edge, but not around the perifoveal area within 0.025 ± 0.01 mm(2). The mean RPC density (0.1556 ± 0.015) and RNFLT (245.96 ± 5.79) were highest at 1.5 mm from ONH margin, and there was a trend in its decline, in a distance-dependent manner, with the least density at 8.5 mm (all P < 0.0001). Highest RPC density was noted in the arcuate fibre region at all the distances. Overall mean RPC density correlated significantly (P < 0.0001) with the overall mean RNFLT. CONCLUSIONS: Wide-field montage OCT-A angiograms can visualize expansion of the RPC network, which is useful in obtaining information about various retinal disorders. The results obtained support the hypothesis that the RPC network could be responsible for RNFL nourishment.

Sita Lakshmi glaucoma center, Anand Eye Institute, 7-147/1, Nagendra Nagar Colony, Habsiguda, Hyderabad, 500007, India. tarannummansoori@yahoo.com.

Full article

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Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)

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