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Abstract #74092 Published in IGR 19-1
Optic Disc Drusen and Family History of Glaucoma - Results of a Patient-directed Survey
Gramer G; Gramer E; Weisschuh NJournal of Glaucoma 2017; 0:
PURPOSE: Prospective evaluation of family history (FH) of glaucoma and FH of optic disc drusen (ODD) in patients with sonographically confirmed ODD. PATIENTS AND METHODS: 87 patients with ODD interviewed all their first and second degree relatives using a detailed questionnaire whether an ophthalmologist had diagnosed or excluded glaucoma or ocular hypertension (OH). Using a second questionnaire, 62 of these patients also provided information about ODD in their FH. Control groups for FH of glaucoma consisted of 2170 patients with glaucoma or OH evaluated with the same methods and identical questions for FH of glaucoma in a previous study, and of 176 healthy individuals without glaucoma or ODD who were interviewed on family history of glaucoma. RESULTS: Glaucoma in FH was significantly more frequent in patients with ODD with 20.7% compared to healthy controls with 2.8%, and half as frequent as in glaucoma patients with 40%. ODD in FH were found in 9.7% of patients with ODD. CONCLUSIONS: As there is a high frequency of family history of glaucoma in patients with ODD, evaluation of FH of ODD and FH of glaucoma is essential in patients with ODD. Glaucoma in FH of ODD patients requires IOP-monitoring and whenever deemed beneficial timely initiation of IOP-lowering therapy.
*University of Heidelberg, Centre for Paediatric and Adolescent Medicine, Division of Neuropaediatrics and Metabolic Medicine, Heidelberg, Germany †University of Würzburg, University Eye Hospital, Würzburg, Germany ‡University of Tübingen, Molecular Genetics Laboratory, Centre for Ophthalmology, Tübingen, Germany.
Full articleClassification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
