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Abstract #74096 Published in IGR 19-1

Is the Optic Nerve Head Structure Impacted by a Diagnostic Lumbar Puncture in Humans?

Poli M; Denis P; Sellem E; Aho-Glélé LS; Bron AM
Journal of Glaucoma 2017; 26: 1036-1040

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PURPOSE: The purpose of this study is to assess in vivo whether diagnostic lumbar puncture (LP) is followed by optic nerve head (ONH) and parapapillary anatomic changes in normal human eyes. MATERIALS AND METHODS: Prospective, single-center, observational case series. ONH structures (prelaminar tissue surface, anterior surface of the lamina cribrosa, central retinal vessels) and parapapillary structures (internal limiting membrane, posterior surfaces of retinal nerve fiber layer and Bruch membrane/retinal pigment epithelium complex, Bruch membrane opening, posterior surface of the choroid) were quantitatively evaluated by means of swept-source optical coherence tomography (Triton Ver.10.05, Topcon, Tokyo, Japan) before and after LP (5, 60, and 360 min). Each of these structures was manually delineated for measurement before being superimposed to detect any displacement, using peripheral margins of parapapillary structures as a reference plane. RESULTS: A total of 16 eyes of 8 nonglaucomatous patients were evaluated. The CSF volume was median (IQR), 1.65 mL (1.16 to 2.00) and none of the ONH structures showed any anatomic changes at any time point after LP. CONCLUSIONS: According to the design of this study, diagnostic LP is a safe procedure regarding deep ONH structures in nonglaucomatous subjects.

*Pôle Vision Val d'Ouest Eye Clinic, Val d'Ouest Private Hospital, Ecully †Department of Ophthalmology, Lyon Sud University Hospital ‡Department of Ophthalmology, Croix-Rousse University Hospital §Centre Ophtalmologique Kleber, Lyon ∥Epidemiology and Infection Control Department ¶Department of Ophthalmology, Dijon University Hospital #Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Burgundy University, Dijon, France.

Full article

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Classification:

2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
9.4.20 Other (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)

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