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pharmacoeconomics (3) 15 Miscellaneous (30)

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Abstract #74124 Published in IGR 19-1

ROCK inhibitors for the treatment of ocular diseases

Nourinia R; Nakao S; Zandi S; Safi S; Hafezi-Moghadam A; Ahmadieh H
British Journal of Ophthalmology 2017; 0:

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The Rho-kinase/ROCK (Rho-associated coiled-coil-containing protein kinase) pathway is involved in the pathogenesis of multiple ocular and systemic disorders. Recently, ROCK inhibitors have been suggested as novel treatments for various ocular diseases. Several in vitro, in vivo and clinical studies have demonstrated the safety and efficacy of ROCK inhibitors in the management of ocular disorders such as corneal epithelial and endothelial damage, glaucoma, retinal and choroidal neovascularisation, diabetic macular oedema and optic nerve disorders. In this review, these studies are explored with focus on the relevant clinical investigations.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Full article

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Classification:

11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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